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Senior Associate Scientist/Scientist/ Senior Scientist- Mammalian Pooled Screens 26 views

Boston, MA

Ginkgo’s mission is to make biology easier to engineer. We are constructing, editing, and redesigning the living world in order to answer the globe’s growing challenges in health, energy, food, materials, and more. Our bioengineers make use of an in-house automated foundry for designing and building new organisms. Today, our foundry is developing over 40 different organisms to make different products across multiple industries.
Ginkgo is continuously crossing new frontiers of biological engineering and we have a record of delivering what was, until recently, thought impossible. Now, our expansion into mammalian cell engineering promises to push our boundaries even further, and so we’re looking for pioneering engineers to make Ginkgo’s new mammalian cell foundry a success.
While cell and gene therapies have seen remarkable success in the clinic, we are at the dawn of a new age in our ability to precisely control gene expression. We’re searching for an outstanding scientist to join our team to execute synthetic promoter discovery screens in mammalian cells. In particular, we are looking for people with experience using recombinase-mediated cassette exchange and other pooled screening techniques. In this role, you will bring your fluency with molecular biology techniques and mammalian cell culture to help optimize and execute RMCE experiments in the context of cell and gene therapy. To be successful in this role, you will think big and execute systematically. You will work closely with a cross-functional technical team to contribute to the optimization of selection strategies, design of barcoding strategies and analysis methods. You will put your organizational and communication muscles to work every day as you work closely with teams across Ginkgo. The level of the position is flexible depending on prior experience. 
Please note this position is located at our Cambridge site
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Responsibilities

  • Contribute to the optimization of RMCE-based integration methods
  • Work with teammates to execute massively parallel pooled screens
  • Independently analyze and interpret experimental results
  • Work with fellow Ginkgo engineers to integrate screens into Ginkgo’s automation and software platforms
  • Maintain laboratory records using Ginkgo internal software tools
  • Contribute to laboratory organization and maintenance
  • Contribute to mammalian team growth and development
  • Desired Experience and Capabilities

  • Title/responsibility commensurate with experience – open to diverse backgrounds and degrees in biology, bio-engineering, or related field
  • Undergraduate degree and 2 years of hands on post-degree research experience,  OR, masters degree and 1 year of hands on post-degree research experience, OR PhD and relevant hands on research experience
  • Experience with mammalian cell engineering or pooled screens, preferably using recombinase-mediated methods
  • Exposure to mammalian synthetic biology, including mammalian construct design, gene editing and/or high-throughput screening
  • Ability to work with interdisciplinary teams in a fast-paced, high-growth environment
  • For more senior candidates, excellent project management skills, with the ability to achieve milestones in a timely manner and communicate project status with stakeholders
  • Additional Preferred Requirements (desired, but not essential)

  • Familiarity with cell and gene therapy
  • Familiarity with laboratory automation 
  • Familiarity with data analysis platforms such as Python, R, and/or JMP 
  • Please note:  this role requires the willingness and ability to share occasional weekend cell culture duties
    To learn more about Ginkgo, check out some recent press:
    We also feel that it’s important to point out the obvious here – there’s a serious lack of diversity in our industry, and that needs to change. Our goal is to help drive that change. Ginkgo is deeply committed to diversity, equity, and inclusion in all of its practices, especially when it comes to growing our team. Our culture promotes inclusion and embraces how rewarding it is to work with people from all walks of life.  
    We’re developing a powerful biological engineering platform, so we must remain mindful of the many ways our technology can – and will – impact people around the world. We care about how our platform is used, and having a diverse team to build it gives us the best chance that it’s something we’ll be proud of as it continues to grow. Therefore, it’s critical that we incorporate the diverse voices and visions of all those who play a role in the future of biology.
    It is the policy of Ginkgo Bioworks to provide equal employment opportunities to all employees and employment applicants.

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    • Active Jobs 97 Jobs
    • Company Address 27 Drydock Avenue, 8th Floor Boston, MA 02210
    • City Boston
    • Location Massachusetts
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