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Senior Scientist – Assay Development 96 views

Boston, MA

Our mission is to make biology easier to engineer. Ginkgo is constructing, editing, and redesigning the living world in order to answer the globe’s growing challenges in health, energy, food, materials, and more. Our bioengineers make use of an in-house automated foundry for designing and building new organisms.
Core to our organism engineering pipeline is the testing and analysis of our engineered strains. We leverage high-throughput screens and selections to measure thousands of strains at a time for improved enzyme activity of key steps or increased titers of final products. Given the diversity of projects at Ginkgo, it is essential that your assay development approaches work across multiple hosts and products of interest. If successful, your novel screening and selection methods will lie at the center of our new high-throughput screening pipelines. Ideally, you have led and contributed hands-on the development of, enzymatic or cell-based assays from conception, development, and piloting through to execution. Further, any experience developing assays and implementing screens towards applications of microbial or mammalian cell line engineering, antibody or vaccine discovery, or effective generation and delivery of viral gene therapy are of high interest.
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Responsibilities

  • The development and optimization of novel enzymatic and cell-based assays to execution of HTS delivering selections for products of interest 
  • Design and execute lab-based experiments, generate and interpret data supporting the successful development of new assays and tests. 
  • Learn, apply, and incorporate automation solutions during assay development, troubleshooting, data analysis, and reporting. 
  • Investigate and identify new methods/technologies to generate reliable and reproducible data promptly
  • Independently plan and execute experiments, adapt readily to changing project needs and develop sophisticated problem-identification and problem-solving skills
  • Requirements

  • PhD degree with 1+ years of post-doctoral training in biology, biochemistry, bioengineering, chemical engineering, or equivalent; OR BS with equivalent experience
  • Experience working as part of a multi-disciplinary team. 
  • Ability to create and establish priorities, manage work plans, and meet timelines.
  • Demonstrated initiative, teamwork, collaboration and passion for developing technical expertise across assay development to routine execution
  • Track record of developing, implementing, and executing screening assays in (384 and/or 1536 well plates) to support projects
  • Familiarity with assay technologies including luminescence, fluorescence and FRET/BRET with experience in the utilization of lab automation across assay development and screening
  • Implementation of assays and screens using next-gen DNA technologies and gene editing (e.g., CRISPR) workflows to enable organism engineering and cell line development
  • Established capabilities in setting-up and operation of microplate readers (e.g., Synergy or PHERAstar), flow cytometer or optofluidic based systems (e.g., ZE5, Beacon) and automated liquid handlers (e.g., Prime, Hamilton, Echo, Tempest) in the development of 384- and/or 1536-well microtiter plate assays
  • Experience in computational analysis of biological data and large data sets using general-purpose programming language (such as Python, R, or Matlab)
  • Familiarity with software and statistical platforms for the analysis of large data sets (e.g., JMP, Tableau, Spotfire, or MODDE pro/DoE)
  • To learn more about Ginkgo, check out some recent press:
    We also feel that it’s important to point out the obvious here – there’s a serious lack of diversity in our industry, and that needs to change. Our goal is to help drive that change. Ginkgo is deeply committed to diversity, equity, and inclusion in all of its practices, especially when it comes to growing our team. Our culture promotes inclusion and embraces how rewarding it is to work with people from all walks of life.  
    We’re developing a powerful biological engineering platform, so we must remain mindful of the many ways our technology can – and will – impact people around the world. We care about how our platform is used, and having a diverse team to build it gives us the best chance that it’s something we’ll be proud of as it continues to grow. Therefore, it’s critical that we incorporate the diverse voices and visions of all those who play a role in the future of biology.
    It is the policy of Ginkgo Bioworks to provide equal employment opportunities to all employees and employment applicants.

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    Company Information
    • Active Jobs 98 Jobs
    • Company Address 27 Drydock Avenue, 8th Floor Boston, MA 02210
    • City Boston
    • Location Massachusetts
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