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Senior Scientist – Biochemical Assay Development 74 views

Boston, MA

Our mission is to make biology easier to engineer. Ginkgo is constructing, editing, and redesigning the living world in order to answer the globe’s growing challenges in health, energy, food, materials, and more. Our bioengineers make use of an in-house automated foundry for designing and building new organisms.
 
Core to our organism engineering pipeline is the testing and analysis of our engineered strains. We leverage high-throughput screens and selections to measure thousands of strains at a time for improved enzyme activity of key steps or increased titers of final products. Given the diversity of projects at Ginkgo, our assay development approaches involve multiple hosts, products of interest, and a wide range of detection strategies. 
 
Assay Development Scientists participate in multi-disciplinary teams of biochemists, metabolic engineers, metabolomics specialists, structural biologists, and HTS operations experts to advance diverse Ginkgo programs. We seek candidates with a strong background in biochemistry/enzymology to develop and optimize enzymatic assays, small-molecule detection strategies, protein interaction assays, and some cell-based assays. Specifically, the Senior Assay Development Scientist will propose assay strategies to measure a wide variety of enzymatic activities, design, execute, and interpret data from laboratory experiments to develop new assays, and aid in the execution of high-throughput screens. Other responsibilities will include learning about and applying new technical and scientific advances to your work, troubleshooting, data analysis, and scientific communication. 
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Responsibilities

  • Propose, develop, and optimize novel and robust enzymatic and small-molecule detection assays for high-throughput screens with a deep understanding of scientific purpose behind screening goals
  • Learn and apply appropriate automation tools during experimentation to efficiently generate high quality data
  • Oversee and execute high throughput screens using appropriate laboratory automation and software tools
  • Analyze large high throughput screening datasets to generate insights for project progress
  • Investigate and identify new assay technologies and approaches and foster an environment for continuous learning
  • Regularly communicate experimental results to a multidisciplinary team of scientists via electronic lab notebooks, presentations, and other mechanisms
  • Reliably identify, communicate, and troubleshoot problems encountered in strategy, experimentation, or data analysis
  • Desired Experience and Capabilities

  • PhD in biochemistry, enzymology, synthetic biocatalysis, biophysics, pharmacology with at least 1 year in a biotech laboratory setting is required, OR MS in the same fields with at least 3 years in a biotech laboratory setting, OR a BS in the same fields with 5 years in a biotech laboratory setting
  • Strong understanding and demonstrated application of basic protein biochemistry and biophysics principles, including those pertaining to enzyme kinetics, coupled biocatalysis, and protein-substrate interactions.
  • Experience applying a wide range of analytical techniques (e.g. absorbance, luminescence & fluorescence-based reporter assays, HTRF, Alpha Screen, OMICs) across a wide range of assay readouts.
  • Familiarity with some laboratory hardware listed such as microplate readers and automated liquid handlers (e.g. Prime, Hamilton, Echo, Tempest)
  • Experience with biophysical protein characterization techniques (e.g. BLI, SPR, ITC) is a strong plus
  • Experience with microbial fermentation at bench scale.
  • Some prior experience with data analysis software such as Spotfire, Tableau, JMP, or GraphPad
  • Experience developing and implementing 384- and/or 1536-well microtiter plate assays is a plus
  • Commitment to technical rigor and detail in small-scale development work as well as high-throughput screen execution and data analysis
  • Strong ability to hone in on scientific priorities, set timelines, and design well-controlled, purpose-driven experiments
  • Demonstrated excellence in written and verbal scientific communication and a passion for working collaboratively with scientists from many backgrounds
  • To learn more about Ginkgo, check out some recent press:
    We also feel that it’s important to point out the obvious here – there’s a serious lack of diversity in our industry, and that needs to change. Our goal is to help drive that change. Ginkgo is deeply committed to diversity, equity, and inclusion in all of its practices, especially when it comes to growing our team. Our culture promotes inclusion and embraces how rewarding it is to work with people from all walks of life.  
    We’re developing a powerful biological engineering platform, so we must remain mindful of the many ways our technology can – and will – impact people around the world. We care about how our platform is used, and having a diverse team to build it gives us the best chance that it’s something we’ll be proud of as it continues to grow. Therefore, it’s critical that we incorporate the diverse voices and visions of all those who play a role in the future of biology.
    It is the policy of Ginkgo Bioworks to provide equal employment opportunities to all employees and employment applicants.

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    • Active Jobs 97 Jobs
    • Company Address 27 Drydock Avenue, 8th Floor Boston, MA 02210
    • City Boston
    • Location Massachusetts
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