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VP of Bioprocess 18 views

Berkeley, CA

About Us
Mission Barns is where some of the world’s smartest, most passionate people are pioneering the future of food. We are scaling up and optimizing our process to provide sustainable, safe, and humane meat products to the world. 
We are a venture-backed startup with decades of experience in cell biology, tissue engineering, media development, food science, bioreactor design, and more. We’re united by our collective drive to solve difficult problems, ask tough questions, and apply cutting-edge science and engineering. At Mission Barns, you’ll have the freedom to dream big and do the best work of your life.
Mission Barns is seeking an industry veteran to build and lead our Bioprocess team. Core parts of the role include developing and optimizing mammalian/avian seed trains, scaling-up/scaling-out GMP-compliant bioreactor systems, and enabling large-scale cell/tissue
Reporting to the CTO, the VP of Bioprocess will have an initial focus on designing and operationalizing a pilot manufacturing system.


  • Full-time, exempt
  • Onsite (not remote) in San Francisco, CA
  • Full time employees enjoy medical, dental and vision coverage, flexible holiday and vacation time, stock options, and ample opportunity for career advancement as the company grows.
  • Responsibilities

  • Build and lead a team of industry-experienced bioprocess scientists/engineers
  • Serve as point person for internal bioreactor tech transfer from our R&D team
  • Refine design, scale-up, and coordinate fabrication of our proprietary bioreactor prototype into a validated, GMP-compliant bioreactor module, including design and integration of process monitoring and control systems
  • Design and coordinate execution of bioprocess optimization and cost-of-goods reduction studies, including biomass yield optimization, culture media usage optimization, media recycling, and evaluation of media feed strategies.
  • Coordinate the drafting of GMP production documentation, including SOPs and batch records with our Director of Quality
  • Coordinate and execute the internal tech transfer of the GMP production bioprocess to the pilot manufacturing team
  • Develop next generation GMP bioreactor systems and further bioprocess optimization and COGs reduction
  • About You

  • PhD or MS in Chemical Engineering, Biochemical Engineering, Bioprocess Engineering, or another relevant engineering discipline
  • 10+ years of industrial experience in upstream mammalian bioprocess scale-up and optimization
  • 5+ years of industrial leadership experience
  • Deep and broad experience implementing GMP and QbD in bioprocesses
  • Demonstrated expertise in mammalian seed train development
  • Demonstrated expertise in designing and coordinating the fabrication of GMP-compliant mammalian cell bioreactor systems
  • Experience in GMP facility build-out, including, but not limited to, drafting of Functional Requirements Specification, Detailed Design Specification, and Process and Instrumentation Diagrams, clean room buildout, sterilization and cleaning infrastructure establishment, culture media and buffer preparation from powdered media
  • Leadership Characteristics

  • Optimistic, open-minded, and inspiring
  • Flexible and adaptable to the pace and pivots of the start-up world
  • Passionate about developing and optimizing novel processes
  • Comfortable building and managing a rapidly growing team
  • Comfortable with ambiguity and uncertainty
  • Preferred Background

  • Experience in commercial-scale culture media formulation and development, particularly mixing and sterile filtration processes, optimization of serum-free media, sourcing of cost-competitive, regulatory-compliant media reagents
  • Experience in business aspects of bioprocess engineering, including, but not limited to, vendor relations and budget management
  • Experience in regulatory and quality considerations, including, but not limited to, establishment of Critical Process Parameters and Critical Quality Attributes, Chemistry, Manufacturing, and Controls compliance, and Biologics License Application submissions.
  • Experience in food processing equipment and regulations
  • Experience in GMP-compliant process automation and Good Automated Manufacturing Practices
  • Experience with DOE approaches
  • Experience in GMP cell isolation protocols
  • Experience with computer-aided design software, and mechanical design and fabrication
  • Full time employees enjoy medical, dental and vision coverage, flexible holiday and vacation time, stock options, and ample opportunity for career advancement as the company grows.
    Mission Barns is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status or disability status.

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    Company Information
    • Active Jobs 19 Jobs
    • Company Address 2618 8th St Berkeley, CA 94710
    • City Berkeley
    • Location California
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